Triethylamine → HCID 89862352, compound

Participants

Reaction Steps

To a solution of Intermediate 3A (1.87 g, 6.19 mmol) and Et3N (1.724 mL, 12.37 mmol) in DCM (30 mL) was added a solution of methanesulfonyl chloride (0.53 mL, 6.8 mmol) in DCM (10 mL) over 1 h at rt. The reaction mixture was stirred at rt for 2.5 h. Additional Et3N (1.724 mL, 12.37 mmol) and methanesulfonyl chloride (0.53 mL, 6.8 mmol) were added and stirred for another 1 h. The reaction mixture was partitioned between 1 N HCl and DCM. The organic layer was dried over Na2SO4, filtered and the solvent was evaporated under reduced pressure to give Intermediate 3B (1.7 g, 5.9 mmol, 97% yield). LC-MS (ESI) m/z 285 (M+H), RT=3.43 min (Method C).

Provenance & Evidence