Trifluoroacetic acid → HCID 83261102, compound

Participants

Reaction Steps

To a solution of Intermediate 3B (1.00 g, 3.52 mmol) in DCM (5 mL) was added TFA (2.5 mL, 32. mmol). The reaction was stirred at rt for 2 h. The reaction mixture was concentrated and purified on a 24 g silica gel column eluted from 0 to 100% EtOAc in hexanes over 15 minutes to Intermediate 3C (650 mg, 2.71 mmol, 77.0% yield). LCMS=241 [M+1], RT=3.59 min (Method A).

Provenance & Evidence