Tert-Butanesulfinamide → HCID 89852658, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 2-methylpropane-2-sulfinamide (339 mg, 2.79 mmol) and 5-(2,2,2-trifluoroethoxy)-3,4-dihydronaphthalen-1(2H)-one (650 mg, 2.66 mmol) in THF (3 mL) was added tetraethoxytitanium (1.10 mL, 5.32 mmol) at rt. The reaction mixture was heated at 75° C. for 14 h. The reaction mixture was cooled to give Intermediate 13A which was used directly in the next step. LCMS=3.86 min [M+1]=347 (Method B).

Provenance & Evidence