HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 117926815, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Propanesulfinamide, 2-methyl-N-[(1S)-1,2,3,4-tetrahydro-5-(2,2,2-trifluoroethoxy)-1-naphthalenyl]-, [S(R)]- | HCID 89853330 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 117926815 | HCID 117926815 | 81.5% |
Reaction Steps
To a solution of Intermediate 13B (245 mg, 0.701 mmol) in DCM (1 mL) was added 4 N HCl (175 μl, 0.701 mmol) in dioxane. The resulting mixture was stirred at rt for 0.5 h. The solvents were evaporated and DCM (3×) was added and evaporated. The resulting white solid was vacuum dried for 1 h to give Intermediate 13 (140 mg, 0.571 mmol, 81.0% yield) as a HCl salt which was used directly without further purification. LCMS=1.48 min [M+1-17]=229 (Method B).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199946B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-18357e93c6d3406cb8159e99fb4fc412 |
| Source note | uspto-grants-2015_12 |