Ethyl isobutyrylacetate → HCID 86682925, compound

HRID 1497044Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[F:17])=O.[CH2:18]([O:20][C:21](=[O:28])[CH2:22][C:23](=O)[CH:24]([CH3:26])[CH3:25])[CH3:19]>>[CH2:18]([O:20][C:21]([C:22]1[C:23]([CH:24]([CH3:26])[CH3:25])=[N:1][C:2]2[C:3]([C:9]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[F:17])=[CH:4][CH:5]=[C:6]([Cl:8])[CH:7]=2)=[O:28])[CH3:19]

Participants

Reactant 2

HCID 81583Ethyl isobutyrylacetate

HCID 27358872-Amino-4-chloro-2'-fluorobenzophenone

Product 1

HCID 86682925HCID 86682925, compound

Procedure

The title compound was prepared in analogy to example 6 step A from a mixture of (2-amino-4-chloro-phenyl)-(2-fluoro-phenyl)-methanone and 4-methyl-3-oxo-pentanoic acid ethyl ester. White solid. MS (ESI): 372.1 (M+H)+.

Sources & evidence

ORD record: ord-f4a00f07f67c4b56a1bfa2d68382d3df
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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