Sodium Hydroxide → HCID 71556225, compound

HRID 1497045Notes

Reaction equation

HRID 1497045 reaction equation
C([O:3][C:4]([C:6]1[C:7]([CH:24]([CH3:26])[CH3:25])=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[F:22])=[CH:13][CH:12]=[C:11]([Cl:23])[CH:10]=2)=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:23][C:11]1[CH:10]=[C:9]2[C:14]([C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])=[C:6]([C:4]([OH:5])=[O:3])[C:7]([CH:24]([CH3:25])[CH3:26])=[N:8]2)=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86682925HCID 86682925, compound

Product 1

HCID 71556225HCID 71556225, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 6 step B from a mixture of 7-chloro-4-(2-fluoro-phenyl)-2-isopropyl-quinoline-3-carboxylic acid ethyl ester and 1N NaOH in ethanol. White solid. MS (ESI): 344.1 (M+H)+.

Sources & evidence

ORD record
ord-618e1a0d218b4e06960487f0fd7fd6c5
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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