Sodium Hydroxide → HCID 71556225, compound

HRID 1497047Notes

Reaction equation

HRID 1497047 reaction equation
C[O:2][C:3]([C:5]1[C:6]([CH:23]([CH3:25])[CH3:24])=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[F:21])=[CH:12][CH:11]=[C:10]([Cl:22])[CH:9]=2)=[O:4].[OH-].[Na+]>C(O)C>[Cl:22][C:10]1[CH:9]=[C:8]2[C:13]([C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])=[C:5]([C:3]([OH:4])=[O:2])[C:6]([CH:23]([CH3:24])[CH3:25])=[N:7]2)=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86682926HCID 86682926, compound

Product 1

HCID 71556225HCID 71556225, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 6 step B from a mixture of 7-chloro-4-(2-fluoro-phenyl)-2-isopropyl-quinoline-3-carboxylic acid methyl ester and 1N NaOH in ethanol. White solid. MS (ESI): 342.0 (M+H)+.

Sources & evidence

ORD record
ord-c7281a7a64af4f94a7a445e2472ff5c7
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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