Sodium Hydroxide → HCID 71556292, compound

HRID 1497060Notes

Reaction equation

HRID 1497060 reaction equation
C([O:3][C:4]([C:6]1[C:7]([CH:25]([CH3:27])[CH3:26])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][CH:10]=2)=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:24][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:25]([CH3:26])[CH3:27])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86682932HCID 86682932, compound

Product 1

HCID 71556292HCID 71556292, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 6 step B from a mixture of 6-chloro-4-(2-chloro-benzyl)-2-isopropyl-quinoline-3-carboxylic acid ethyl ester (30 mg, 0.074 mmol) and 1N NaOH in ethanol. White solid (16 mg, 57%) LC-MS: 374 (M+H)+.

Sources & evidence

ORD record
ord-7ae7433f394349fb8a5e394fd2154982
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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