HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2,6-dichloro-4-phenylquinoline-3-carboxylate → 6-Chloro-2-(4,4-difluoro-piperidin-1-yl)-4-phenyl-quinoline-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2,6-dichloro-4-phenylquinoline-3-carboxylate | HCID 1714247 | — |
| Reactant | 4,4-Difluoropiperidine | HCID 2758352 | — |
| Product | 6-Chloro-2-(4,4-difluoro-piperidin-1-yl)-4-phenyl-quinoline-3-carboxylic acid ethyl ester | HCID 86682935 | — |
Reaction Steps
The title compound was prepared in analogy to example 11 step C from 2,6-dichloro-4-phenyl-quinoline-3-carboxylic acid ethyl ester (prepared as described in example 11 step B) and 4,4-difluoro-piperidine. Pale yellow solid (110 mg, 44%). LC-MS: 431 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199938B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-140d26d70e0342579440e83b975567d6 |
| Source note | uspto-grants-2015_12 |