Methyl malonyl chloride → HCID 86682941, compound

Participants

Reaction Steps

Methyl 3-chloro-3-oxopropanoate (317 mg, 249 μl, 2.25 mmol, Eq: 1.2) was added dropwise to a yellow solution of (2-amino-3,5-dichloro-phenyl)-phenyl-methanone (500 mg, 1.88 mmol, Eq: 1.00) in DCM (5 ml) at 0° C. The yellow solution was then allowed to warm slowly to RT. After completion of the reaction the mixture was washed with sat. NaHCO3 solution and brine, dried with Na2SO4 and evaporated. The remaining light brown residue (603 mg) was used in the next reaction step without further purification. MS (ESI): 366.0 (M+H)+.

Provenance & Evidence