Water → HCID 86682947, compound

Participants

Reaction Conditions

Reaction Steps

2,6-Dichloro-4-phenyl-quinoline-3-carbonitrile (30 mg, 100 μmol, Eq: 1.00), pyrrolidine (14.3 mg, 16.6 μl, 201 μmol, Eq: 2) and triethylamine (30.4 mg, 41.9 μl, 301 μmol, Eq: 3) were dissolved in DMF (0.5 ml) and the reaction mixture was heated to 120° C. for 20 min in a microwave. Then water was added and the mixture was extracted with ethyl acetate (3×). The combined organic layers were dried with Na2SO4 and evaporated to dryness. The remaining residue was purified by column chromatography (silica gel, DCM/heptane 1:1) to afford the title compound as yellow solid (28 mg). MS (ESI): 334.2 (M+H)+.

Provenance & Evidence