Sodium Hydroxide → HCID 71556426, compound

HRID 1497091Notes

Reaction equation

HRID 1497091 reaction equation
C([O:3][C:4]([C:6]1[C:7]([N:25]([CH3:27])[CH3:26])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][CH:10]=2)=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:24][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:25]([CH3:26])[CH3:27])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86682951HCID 86682951, compound

Product 1

HCID 71556426HCID 71556426, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 12 step B from a mixture of 6-chloro-4-(2-chloro-benzyl)-2-dimethylamino-quinoline-3-carboxylic acid ethyl ester and 1N NaOH in ethanol. Pale yellow solid. LC-MS (ESI): 375 (M+H)+.

Sources & evidence

ORD record
ord-9846f72d0c7e4595956a378bbd76cbb0
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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