3-Isopropylbenzeneboronic acid → HCID 86682954, compound

HRID 1497094Notes

Reaction equation

HRID 1497094 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6]([CH:17]([CH3:19])[CH3:18])=[N:7][C:8]2[C:13]([C:14]=1Cl)=[CH:12][C:11]([Cl:16])=[CH:10][CH:9]=2)=[O:4].[CH:20]([C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1)([CH3:22])[CH3:21]>>[CH3:1][O:2][C:3]([C:5]1[C:6]([CH:17]([CH3:19])[CH3:18])=[N:7][C:8]2[C:13]([C:14]=1[C:27]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:20]([CH3:22])[CH3:21])[CH:28]=1)=[CH:12][C:11]([Cl:16])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27734783-Isopropylbenzeneboronic acidHCID 86682953HCID 86682953, compound

Product 1

HCID 86682954HCID 86682954, compound

Procedure

The title compound was prepared in analogy to example 20 step C from 4,6-dichloro-2-isopropyl-quinoline-3-carboxylic acid methyl ester (200 mg, 0.67 mmol) and 3-isopropylphenylboronic acid (99 mg, 0.6 mmol). Off-white sticky liquid (90 mg, 35%). LC-MS: 382 (M+H)+.

Sources & evidence

ORD record
ord-eeb6ce93bb3d46a78684f0f46350ec72
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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