3-Ethoxybenzeneboronic acid → HCID 86682955, compound

HRID 1497096Notes

Reaction equation

HRID 1497096 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6]([CH:17]([CH3:19])[CH3:18])=[N:7][C:8]2[C:13]([C:14]=1Cl)=[CH:12][C:11]([Cl:16])=[CH:10][CH:9]=2)=[O:4].[CH2:20]([O:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1)[CH3:21]>>[CH3:1][O:2][C:3]([C:5]1[C:6]([CH:17]([CH3:19])[CH3:18])=[N:7][C:8]2[C:13]([C:14]=1[C:27]1[CH:26]=[CH:25][CH:24]=[C:23]([O:22][CH2:20][CH3:21])[CH:28]=1)=[CH:12][C:11]([Cl:16])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27739203-Ethoxybenzeneboronic acidHCID 86682953HCID 86682953, compound

Product 1

HCID 86682955HCID 86682955, compound

Procedure

The title compound was prepared in analogy to example 20 step C from 4,6-dichloro-2-isopropyl-quinoline-3-carboxylic acid methyl ester (prepared as described in example 31 step A, 200 mg, 0.67 mmol) and 3-ethoxyphenylboronic acid (72 mg, 0.54 mmol). Sticky liquid (105 mg, 41%). LC-MS: 384 (M+H)+.

Sources & evidence

ORD record
ord-a8ddfbce1c9d4a748b54743b4e9a0599
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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