3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 86682958, compound

HRID 1497101Notes

Reaction equation

HRID 1497101 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6]([CH:17]([CH3:19])[CH3:18])=[N:7][C:8]2[C:13]([C:14]=1Br)=[CH:12][C:11]([Cl:16])=[CH:10][CH:9]=2)=[O:4].[Cl:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][C:26]=1[F:27]>>[CH3:1][O:2][C:3]([C:5]1[C:6]([CH:17]([CH3:19])[CH3:18])=[N:7][C:8]2[C:13]([C:14]=1[C:23]1[CH:24]=[CH:25][C:26]([F:27])=[C:21]([Cl:20])[CH:22]=1)=[CH:12][C:11]([Cl:16])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 86682940HCID 86682940, compound

Product 1

HCID 86682958HCID 86682958, compound

Procedure

The title compound was prepared in analogy to example 20 step C from 4-bromo-6-chloro-2-isopropyl-quinoline-3-carboxylic acid methyl ester (prepared as described in example 20 step B, 150 mg, 0.44 mmol) and 3-chloro-4-fluorophenylboronic acid (62 mg, 0.35 mmol) as off white solid (70 mg, 41%). LC-MS: 392 (M+H)+.

Sources & evidence

ORD record
ord-e0adfb6637604639957720d2a27023f9
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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