N-Methylisopropylamine → HCID 86682966, compound

HRID 1497114Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](OS(C(F)(F)F)(=O)=O)[C:6]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[C:5]2[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[CH3:33][NH:34][CH:35]([CH3:37])[CH3:36]>>[C:23]([O:22][C:20]([C:6]1[C:7]([N:34]([CH:35]([CH3:37])[CH3:36])[CH3:33])=[N:8][C:9]2[C:4]([C:5]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[CH:3][C:2]([Cl:1])=[CH:11][CH:10]=2)=[O:21])([CH3:25])([CH3:24])[CH3:26]

Participants

Reactant 2

HCID 78485N-Methylisopropylamine

HCID 86682967HCID 86682967, compound

Product 1

HCID 86682966HCID 86682966, compound

Procedure

The title compound was prepared in analogy to example 92 step A from tert-butyl 6-chloro-4-phenyl-2-(trifluoromethylsulfonyloxy)quinoline-3-carboxylate (prepared in analogy to example 91 step A to C, 100 mg, 0.21 mmol) and N-methylpropan-2-amine (0.213 ml, 2.05 mmol). Pale yellow solid (75 mg, 89%). MS (ESI): 411 (M+H)+.

Sources & evidence

ORD record: ord-e56878e060f64e25b49fcc39ad13f646
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

Loading…