2-(Methylamino)ethanol → HCID 86682969, compound

HRID 1497119Notes

Reaction equation

HRID 1497119 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](OS(C(F)(F)F)(=O)=O)[C:6]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[C:5]2[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[CH3:33][NH:34][CH2:35][CH2:36][OH:37]>>[C:23]([O:22][C:20]([C:6]1[C:7]([N:34]([CH2:35][CH2:36][OH:37])[CH3:33])=[N:8][C:9]2[C:4]([C:5]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[CH:3][C:2]([Cl:1])=[CH:11][CH:10]=2)=[O:21])([CH3:26])([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 86682967HCID 86682967, compound

Product 1

HCID 86682969HCID 86682969, compound

Procedure

The title compound was prepared in analogy to example 92 step A from tert-butyl 6-chloro-4-phenyl-2-(trifluoromethylsulfonyloxy)quinoline-3-carboxylate (prepared in analogy to example 91 step A to C, 100 mg, 0.21 mmol) and 2-(methylamino)ethanol (0.164 ml, 2.05 mmol). Pale yellow solid (65 mg, 77%). MS (ESI): 413 (M+H)+.

Sources & evidence

ORD record
ord-9d970607b50b4fb292710c7fff181b18
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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