1,1,1-Trifluoro-2-propanol → HCID 86682973, compound

HRID 1497129Notes

Reaction equation

HRID 1497129 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](Cl)=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])[CH3:2].[F:24][C:25]([F:30])([F:29])[CH:26]([OH:28])[CH3:27]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:28][CH:26]([CH3:27])[C:25]([F:30])([F:29])[F:24])=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 97741,1,1-Trifluoro-2-propanolHCID 1714247Ethyl 2,6-dichloro-4-phenylquinoline-3-carboxylate

Product 1

HCID 86682973HCID 86682973, compound

Procedure

The title compound was prepared in analogy to example 37 step A from 2,6-dichloro-4-phenyl-quinoline-3-carboxylic acid ethyl ester (prepared as described in example 11 step B, 100 mg, 0.29 mmol) and 1,1,1-trifluoro-propan-2-ol (40 mg, 0.35 mmol). Pale yellow solid (76 mg, 62%). LC-MS: 424 (M+H)+.

Sources & evidence

ORD record
ord-84b2f7f0242744e881f5c4d5de1036a7
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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