Methyl malonyl chloride → HCID 86682974, compound

HRID 1497131Notes

Reaction equation

HRID 1497131 reaction equation
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11].Cl[C:19](=[O:25])[CH2:20][C:21]([O:23][CH3:24])=[O:22]>>[CH3:24][O:23][C:21](=[O:22])[CH2:20][C:19]([NH:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[C:10](=[O:11])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:25]

Participants

3

Reactant 2

HCID 123460Methyl malonyl chlorideHCID 86682975HCID 86682975, compound

Product 1

HCID 86682974HCID 86682974, compound

Procedure

The title compound was prepared in analogy to example 21 step A from (2-amino-5-bromo-3-methyl-phenyl)-phenyl-methanone and methyl 3-chloro-3-oxopropanoate. Light yellow solid. MS (ESI): 392.1 (M+H)+.

Sources & evidence

ORD record
ord-f8925f182a4a4a11b3e4810971889556
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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