4,4-Difluoropiperidine → HCID 71556687, compound

HRID 1497136Notes

Reaction equation

HRID 1497136 reaction equation
C[O:2][C:3]([C:5]1[C:6](Cl)=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([Cl:21])=[CH:10][C:9]=2[CH3:22])=[O:4].[F:24][C:25]1([F:31])[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[Cl:21][C:11]1[CH:12]=[C:13]2[C:8](=[C:9]([CH3:22])[CH:10]=1)[N:7]=[C:6]([N:28]1[CH2:29][CH2:30][C:25]([F:31])([F:24])[CH2:26][CH2:27]1)[C:5]([C:3]([OH:2])=[O:4])=[C:14]2[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 27583524,4-DifluoropiperidineHCID 86682965HCID 86682965, compound

Product 1

HCID 71556687HCID 71556687, compound

Procedure

The title compound was prepared in analogy to example 40 step D from 2,6-dichloro-8-methyl-4-phenyl-quinoline-3-carboxylic acid methyl ester (prepared as described in example 40 step C) and 4,4-difluoro-piperidine. Light yellow foam. MS (ESI): 417.2 (M+H)+.

Sources & evidence

ORD record
ord-0635b277ad584cadaecfd84ba3ef5d72
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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