Water → HCID 86682979, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6-bromo-8-methyl-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxylic acid methyl ester (prepared as described in example 54 step C) (140 mg, 376 μmol, Eq: 1.00) and copper(I) cyanide (121 mg, 41.5 μl, 1.35 mmol, Eq: 3.6) in DMF (2.8 ml) was heated to 130° C. for 2 d. Then water was added and the mixture was extracted with DCM (3×). The combined extracts were washed with water and brine, dried with Na2SO4 and evaporated to give the title compound as off-white solid (120 mg). MS (ESI): 317.2 (M−H)−

Provenance & Evidence