HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 6-Chloro-4-(2-chloro-benzyl)-8-fluoro-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-[4-Chloro-2-(2-chloro-phenylethynyl)-6-fluoro-phenyl]-malonamic acid ethyl ester | HCID 86682982 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-Chloro-4-(2-chloro-benzyl)-8-fluoro-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester | HCID 86682983 | — |
Reaction Steps
The title compound was prepared in analogy to example 29 step B from N-[4-Chloro-2-(2-chloro-phenylethynyl)-6-fluoro-phenyl]-malonamic acid ethyl ester (217 mg, 0.55 mmol) and NaH (33 mg, 0.83 mmol) in DMSO. Off white solid (120 mg, 55%). MS (ESI): 394 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199938B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-2994fb87b8fd4959b76032c4b21b0d41 |
| Source note | uspto-grants-2015_12 |