Sodium Hydroxide → HCID 71556751, compound

HRID 1497145Notes

Reaction equation

HRID 1497145 reaction equation
C([O:3][C:4]([C:6]1[C:7]([NH:26][CH3:27])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][C:10]=2[F:25])=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:24][C:12]1[CH:13]=[C:14]2[C:9](=[C:10]([F:25])[CH:11]=1)[N:8]=[C:7]([NH:26][CH3:27])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86682985HCID 86682985, compound

Product 1

HCID 71556751HCID 71556751, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 12 step B from a mixture of 6-chloro-4-(2-chloro-benzyl)-8-fluoro-2-methylamino-quinoline-3-carboxylic acid ethyl ester and 1N NaOH in ethanol. Light yellow solid. MS (ESI): 379 (M+H)+.

Sources & evidence

ORD record
ord-b5a0c735d7df4bfcb72fb7ce0f9e1df3
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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