N-Methylethylamine → HCID 71556754, compound

HRID 1497148Notes

Reaction equation

C[O:2][C:3]([C:5]1[C:6](Cl)=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([C:21]#[N:22])=[CH:10][C:9]=2[CH3:23])=[O:4].[CH2:25]([NH:27][CH3:28])[CH3:26]>>[C:21]([C:11]1[CH:12]=[C:13]2[C:8](=[C:9]([CH3:23])[CH:10]=1)[N:7]=[C:6]([N:27]([CH2:25][CH3:26])[CH3:28])[C:5]([C:3]([OH:2])=[O:4])=[C:14]2[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)#[N:22]

Participants

Reactant 2

HCID 12219N-Methylethylamine

HCID 86682980HCID 86682980, compound

Product 1

HCID 71556754HCID 71556754, compound

Procedure

The title compound was prepared in analogy to example 60 step C from 2-chloro-6-cyano-8-methyl-4-phenyl-quinoline-3-carboxylic acid methyl ester (prepared as described in example 60 step B) and ethyl-methyl-amine. Off-white solid. MS (ESI): 346.2 (M+H)+.

Sources & evidence

ORD record: ord-41772a3e4a0143998656722c66641d3c
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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