Potassium Phosphate, Tribasic → HCID 86682997, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6,8-dichloro-2-isopropyl-4-trifluoromethanesulfonyloxy-quinoline-3-carboxylic acid methyl ester (85.0 mg, 0.181 mmol, Eq: 1.00), 3-chloro-4-fluorophenylboronic acid (34.7 mg, 0.199 mmol, Eq: 1.1), potassium phosphate tribasic (57.7 mg, 0.272 mmol, Eq: 1.5) and tetrakis(triphenylphosphine)palladium (0) (6.27 mg, 0.00543 mmol, Eq: 0.0300) in dioxane (2.5 ml) was heated to 100° C. for 4 h. The suspension was cooled to RT overnight, then diluted with sat. NH4Cl solution and extracted with ethyl acetate (3×). The combined organic layers were washed with sat. NH4Cl solution and brine, dried with Na2SO4 and evaporated. The remaining residue was purified by column chromatography (silica gel, heptane/EtOAc 99:1) to afford the title compound as white solid (46 mg). MS (ESI): 426.0 (M+H)+.

Provenance & Evidence