Lithium iodide → HCID 71556820, compound

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Reaction Steps

A solution of 6,8-dichloro-4-(3-chloro-4-fluoro-phenyl)-2-isopropyl-quinoline-3-carboxylic acid methyl ester (42.0 mg, 0.0984 mmol, Eq: 1.00) and lithium iodide (132 mg, 0.984 mmol, Eq: 10.0) in pyridine (1.5 ml) was heated to 135° C. overnight. The pyridine was then removed in vacuo and the remaining residue was diluted with water. The pH was adjusted to 12 by addition of 0.1N NaOH and the mixture was extracted with diethylether/heptane (60:40) (3×). The aqueous layer was acidified with 0.1N HCl to pH 3 and extracted with CHCl3 (3×). The combined CHCl3 layers were dried with Na2SO4 and evaporated to yield the title compound as white foam (35 mg). MS (ESI): 412.1 (M+H)+.

Provenance & Evidence