Ethyl isobutyrylacetate → HCID 86683002, compound

HRID 1497164Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([NH2:9])=[C:4]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[CH:3]=1.[CH2:19]([O:21][C:22](=[O:29])[CH2:23][C:24](=O)[CH:25]([CH3:27])[CH3:26])[CH3:20]>>[CH2:19]([O:21][C:22]([C:23]1[C:24]([CH:25]([CH3:27])[CH3:26])=[N:9][C:5]2[C:4]([C:10]=1[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=2[CH3:8])=[O:29])[CH3:20]

Participants

Reactant 2

HCID 81583Ethyl isobutyrylacetate

HCID 86683001HCID 86683001, compound

Product 1

HCID 86683002HCID 86683002, compound

Procedure

The title compound was prepared in analogy to example 10 step B from 4-chloro-2-(2-chloro-phenylethynyl)-6-methyl-phenylamine (400 mg, 1.45 mmol) and 4-methyl-3-oxo-pentanoic acid ethyl ester (0.351 ml, 2.17 mmol). Brown solid. LC-MS (ESI): 416 (M+H)+.

Sources & evidence

ORD record: ord-76d1611d88c7446d9c8da6b848a00850
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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