Potassium Hydroxide → HCID 86683006, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (2-amino-5-chloro-phenyl)-(3-isopropyl-phenyl)-methanone (1.1 g, 4.02 mmol), and malonic acid di-tert-butyl ester (1.344 ml, 6.03 mmol) was added potassium hydroxide (113 mg, 2.01 mmol) at 25° C., and the resulting reaction mixture was stirred at 110° C. for 16 h. It was cooled to 0° C., and directly purified by column chromatography over silica gel (20-30% EtOAc/hexane) to afford 6-chloro-4-(3-isopropyl-phenyl)-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid tert-butyl ester (700 mg, 44%) as pale yellow solid. LC-MS (ESI): 398 (M+H)+.

Provenance & Evidence