Sodium hydride → 6-Chloro-4-(2-chloro-benzyl)-2-oxo-8-trifluoromethyl-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester

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Reaction Steps

The title compound was prepared in analogy to example 29 step B from N-[4-chloro-2-(2-chloro-phenylethynyl)-6-trifluoromethyl-phenyl]-malonamic acid ethyl ester (1 g, 2.25 mmol) and NaH (140 mg, 3.38 mmol) in DMSO (10 ml). Off white solid (450 mg, 45%). LC-MS (ESI): 444 (M+H)+.

Provenance & Evidence