Dimethylamine → HCID 86683018, compound

HRID 1497191Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[C:7](OS(C(F)(F)F)(=O)=O)=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][C:10]=2[C:25]([F:28])([F:27])[F:26])=[O:5])[CH3:2].[CH3:37][NH:38][CH3:39]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([N:38]([CH3:39])[CH3:37])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][C:10]=2[C:25]([F:27])([F:26])[F:28])=[O:5])[CH3:2]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 86683019HCID 86683019, compound

Product 1

HCID 86683018HCID 86683018, compound

Procedure

The title compound was prepared in analogy to example 29 step D from 6-chloro-4-(2-chloro-benzyl)-2-trifluoromethanesulfonyloxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester (80 mg, 0.14 mmol) and dimethylamine (3 ml, 2M solution in THF). Off white solid (45 mg, 69%). LC-MS (ESI): 471 (M+H)+

Sources & evidence

ORD record: ord-d322e9a4123441679a1ed3ad3e2b1804
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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