Sodium Hydroxide → HCID 71555923, compound

HRID 1497195Notes

Reaction equation

C([O:3][C:4]([C:6]1[C:7]([N:25]([CH2:28][CH3:29])[CH2:26][CH3:27])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][CH:10]=2)=[O:5])C.[OH-].[Na+]>>[Cl:24][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:25]([CH2:28][CH3:29])[CH2:26][CH3:27])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86683020HCID 86683020, compound

Product 1

HCID 71555923HCID 71555923, compound

Procedure

The title compound was prepared in analogy to example 12 step B from a mixture of 6-chloro-4-(2-chloro-benzyl)-2-diethylamino-quinoline-3-carboxylic acid ethyl ester (50 mg, 0.116 mmol) and 1N NaOH. Pale yellow solid (32 mg, 68%). LC-MS (ESI): 403 (M+H)+.

Sources & evidence

ORD record: ord-601d605036c247428e783aaf46fd9ba1
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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