Sodium Hydroxide → HCID 71555924, compound

HRID 1497197Notes

Reaction equation

HRID 1497197 reaction equation
C([O:3][C:4]([C:6]1[C:7]([N:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][CH:10]=2)=[O:5])C.[OH-].[Na+]>>[Cl:24][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1)[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86683021HCID 86683021, compound

Product 1

HCID 71555924HCID 71555924, compound

Procedure

The title compound was prepared in analogy to example 12 step B from 6-chloro-4-(2-chloro-benzyl)-2-pyrrolidin-1-yl-quinoline-3-carboxylic acid ethyl ester (50 mg, 0.117 mmol) and 1N NaOH. Pale yellow solid (13 mg, 28%). LC-MS (ESI): 401 (M+H)+.

Sources & evidence

ORD record
ord-e68c3bba996742528399c0d9ea8d2d28
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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