HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 6-Chloro-2-oxo-4-(2-trifluoromethyl-benzyl)-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-[4-Chloro-2-(2-trifluoromethyl-phenylethynyl)-phenyl]-malonamic acid ethyl ester | HCID 86683024 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-Chloro-2-oxo-4-(2-trifluoromethyl-benzyl)-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester | HCID 86683025 | — |
Reaction Steps
The title compound was prepared in analogy to example 29 step B from N-[4-chloro-2-(2-trifluoromethyl-phenylethynyl)-phenyl]-malonamic acid ethyl ester (213 mg, 0.52 mmol) and NaH (31.2 mg, 0.78 mmol) in DMSO. Off white solid (95 mg, 45%). MS (ESI): 410 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199938B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-7321ed9b73fe4b10ba9019721b4d7968 |
| Source note | uspto-grants-2015_12 |