Sodium Hydroxide → HCID 71555988, compound

HRID 1497204Notes

Reaction equation

HRID 1497204 reaction equation
C([O:3][C:4]([C:6]1[C:7]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]([F:26])([F:25])[F:24])=[CH:13][C:12]([Cl:27])=[CH:11][CH:10]=2)=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:27][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]([F:26])([F:24])[F:25]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86683026HCID 86683026, compound

Product 1

HCID 71555988HCID 71555988, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 12 step B from a mixture of 6-chloro-2-piperidin-1-yl-4-(2-trifluoromethyl-benzyl)-quinoline-3-carboxylic acid ethyl ester and 1N NaOH in ethanol. Pale yellow solid. MS (ESI): 449 (M+H)+.

Sources & evidence

ORD record
ord-919187fffc39423eb9d8464fd7b3c26a
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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