反应详情

温度

110 °C

A mixture of (2-amino-5-chloro-phenyl)-(3-chloro-phenyl)-methanone (550 mg, 2.07 mmol), KOH (58 mg, 1.03 mmol) and malonic acid di-tert-butyl ester (0.7 ml, 3.1 mmol) was placed in a sealed tube, and the resulting reaction mixture was stirred at 110° C. for 16 h. After cooling, the reaction mixture was purified by flash column chromatography (20-30% ethyl acetate in hexane) to give 6-chloro-4-(3-chloro-phenyl)-2-hydroxy-quinoline-3-carboxylic acid tert-butyl ester (410 mg, 51%) as an off white solid. LC-MS (ESI): 390 (M+H)+.

1. customwas placed in a sealed tube
2. customthe resulting reaction mixture
3. temperatureAfter cooling
4. customthe reaction mixture was purified by flash column chromatography (20-30% ethyl acetate in hexane)