HCID 86683031, compound → HCID 86683030, compound

Participants

Reaction Steps

A solution of 6-chloro-4-(3-chloro-phenyl)-2-diethylamino-quinoline-3-carboxylic acid tert-butyl ester (60 mg, 0.13 mmol) in 3 ml of 4M HCl solution in dioxane was heated to reflux and stirred for 4 h. The reaction mixture was cooled to room temperature and concentrated in vacuo. The crude residue was diluted with ethyl acetate (25 ml) and washed with brine (5 ml). The organic layer was dried over anhydrous sodium sulphate and concentrated in vacuo to yield 6-chloro-4-(3-chloro-phenyl)-2-diethylamino-quinoline-3-carboxylic acid (45 mg, 86%) as a pale yellow solid. LC-MS (ESI): 389 (M+H)+.

Provenance & Evidence