1,1,1-Trifluoro-2-propanol → HCID 86683039, compound

HRID 1497216Notes

Reaction equation

HRID 1497216 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:25]S(C(F)(F)F)(=O)=O)=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][CH:10]=2)=[O:5])[CH3:2].[F:33][C:34]([F:39])([F:38])[CH:35](O)[CH3:36]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:25][CH:35]([CH3:36])[C:34]([F:39])([F:38])[F:33])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][CH:10]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 97741,1,1-Trifluoro-2-propanolHCID 86682952HCID 86682952, compound

Product 1

HCID 86683039HCID 86683039, compound

Procedure

This compound was prepared in analogy to example 29 step D from 6-chloro-4-(2-chloro-benzyl)-2-trifluoromethanesulfonyloxy-quinoline-3-carboxylic acid ethyl ester (prepared as described in example 29 step C, 75 mg, 0.15 mmol) and 1,1,1-trifluoro-propan-2-ol (0.026 ml, 0.2 mmol). Off white solid (10 mg, 14%). LC-MS (ESI): 472 (M+H)+.

Sources & evidence

ORD record
ord-2ed8c20513bb4ad79b01a695c91d241a
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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