Water → HCID 86683046, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,6-dichloro-4-(3-isopropyl-phenyl)-quinoline-3-carbonitrile (128 mg, 375 μmol, Eq: 1.00), diethylamine (54.9 mg, 78.4 μl, 750 μmol, Eq: 2) and triethylamine (114 mg, 157 μl, 1.13 mmol, Eq: 3) in DMF (1 ml) was heated first to 120° C. for 20 min and then to 180° C. for additional 20 min in a microwave. Then water was added and the mixture was extracted with ethyl acetate (3×). The combined extracts were washed with water and brine, dried with Na2SO4 and evaporated. The remaining residue was purified by column chromatography (silica gel, heptane/EtOAc 90:10 to 85:15) to afford the title compound as yellow oil (128 mg). MS (ESI): 377.1 (M−H)−.

Provenance & Evidence