Diethyl Ether → (2-Amino-5-chloro-4-fluoro-phenyl)-phenyl-methanone

A solution of phenylmagnesium bromide (7.18 ml, 3M solution in diethyl ether, 21.5 mmol) in diethyl ether (15 ml) was added to a solution of 2-amino-5-chloro-4-fluoro-benzonitrile (1225 mg, 7.18 mmol) in diethyl ether (20 ml) at 0° C. The reaction mixture was then stirred at reflux for 2 h, cooled to room temperature and quenched carefully by addition of 2N HCl (˜40 ml). The mixture was heated to 55° C. for 3 h and then cooled to room temperature again. 3N NaOH (˜20 ml) was added carefully at 0° C. to adjust the pH to 9. The mixture was extracted with EtOAc and the combined extracts were washed with brine, dried with Na2SO4 and evaporated. The remaining residue was purified by column chromatography (silica gel, heptane/EtOAc 95:5-90:10) to afford the title compound (1667 mg, 93%) as yellow solid. MS (ESI): 250.3 (M+H)+.

1. temperatureat reflux for 2 h
2. customquenched carefully by addition of 2N HCl (˜40 ml)
3. temperatureThe mixture was heated to 55° C. for 3 h
4. temperaturecooled to room temperature again
5. addition3N NaOH (˜20 ml) was added carefully at 0° C.
6. extractionThe mixture was extracted with EtOAc
7. washthe combined extracts were washed with brine
8. dry with materialdried with Na2SO4
9. customevaporated
10. customThe remaining residue was purified by column chromatography (silica gel, heptane/EtOAc 95:5-90:10)

ORD record

ord-2271dd8c6025457681eaad032d26bd05

Source dataset

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09199938B2