(2-Amino-5-chloro-4-fluoro-phenyl)-phenyl-methanone → HCID 178518644, compound

HRID 1497246Notes

Reaction equation

HRID 1497246 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([Cl:9])=[CH:4][C:3]=1[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O.[NH:18]1[C:22]([CH2:23][C:24](O)=[O:25])=[N:21][N:20]=[N:19]1>>[Cl:9][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][C:6]=1[F:8])[NH:1][C:24](=[O:25])[C:23]([C:22]1[NH:21][N:20]=[N:19][N:18]=1)=[C:10]2[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 86683059(2-Amino-5-chloro-4-fluoro-phenyl)-phenyl-methanoneHCID 178525261HCID 178525261, compound

Product 1

HCID 178518644HCID 178518644, compound

Procedure

The title compound was prepared in analogy to example 102 step A from (2-amino-5-chloro-4-fluoro-phenyl)-phenyl-methanone (prepared as described in example 105 step D) and 2-(1H-tetrazol-5-yl)acetic acid. Off-white solid. MS (ESI): 342.4 (M+H)+.

Sources & evidence

ORD record
ord-cc833f66cb6a4f9ab4faf03c54626f39
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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