Cesium carbonate → HCID 86683086, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-bromo-2-cyclopentyl-6-trifluoromethyl-quinoline-3-carbonitrile (130 mg, 352 μmol), 2-methylpyridine-4-boronic acid pinacol ester (92.6 mg, 423 μmol), cesium carbonate (103 mg, 317 μmol) and tetrakis(triphenylphosphine)palladium (0) (40.7 mg, 35.2 μmol) in DMF (5.2 ml) was heated to 90° C. for 16 h. The reaction mixture was poured on water and extracted with EtOAc. The combined extracts were washed with water and brine, dried with Na2SO4 and evaporated. The remaining solid was purified by column chromatography (silica gel, n-heptane/EtOAc 4:1) to afford the title compound (20 mg, 15%) as off-white solid. MS (ESI): 382.6 (M+H)+.

Provenance & Evidence