3-Cyclohexyl-3-oxopropanenitrile → HCID 86683087, compound

HRID 1497274Notes

Reaction equation

HRID 1497274 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][N:14]=[C:13]([CH3:17])[CH:12]=1)=O.[CH:18]1([C:24](=O)[CH2:25][C:26]#[N:27])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[Cl:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:24]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:25]([C:26]#[N:27])=[C:9]2[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([CH3:17])[CH:12]=1

Participants

3

Reactant 2

HCID 113095973-Cyclohexyl-3-oxopropanenitrileHCID 22327293(2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone

Product 1

HCID 86683087HCID 86683087, compound

Procedure

The title compound was prepared in analogy to example 101 step B from (2-amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone and 3-cyclohexyl-3-oxo-propionitrile (prepared as described in example 110 step A). White solid. MS (ESI): 362.5 (M+H)+.

Sources & evidence

ORD record
ord-4e9a06687a7f4071a316511dfc9610a3
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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