(2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone → HCID 86683089, compound

HRID 1497276Notes

Reaction equation

HRID 1497276 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][N:14]=[C:13]([CH3:17])[CH:12]=1)=O.[CH2:18]([CH:20]([CH2:26][CH3:27])[C:21](=O)[CH2:22][C:23]#[N:24])[CH3:19]>>[Cl:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:21]([CH:20]([CH2:26][CH3:27])[CH2:18][CH3:19])[C:22]([C:23]#[N:24])=[C:9]2[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([CH3:17])[CH:12]=1

Participants

3

Reactant 2

HCID 22327293(2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanoneHCID 235057484-Ethyl-3-oxohexanenitrile

Product 1

HCID 86683089HCID 86683089, compound

Procedure

The title compound was prepared in analogy to example 101 step B from (2-amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone (prepared in analogy to example 126 step B) and 4-ethyl-3-oxo-hexanenitrile (prepared as described in example 101 step A). Yellow solid. MS (ESI): 350.5 (M+H)+.

Sources & evidence

ORD record
ord-f546cae652734f529cdb052ddb9acd4c
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

Loading…