Triethylamine → (2,6-Dichloro-pyrimidin-4-yl)-(2,4-difluoro-benzyl)-amine

Participants

Reaction Steps

A suspension of methyl 2,4,6-trichloropyrimidine (1 g, 4.87 mmol) in methanol (20 ml) was cooled −20° C., to this 2,4-difluoro benzylamine (0.627 mg, 4.39 mmol) and triethylamine (0.98 mg, 9.74 mmol) were added. RM was stirred at same temperature for 1 hr then at room temperature for 4 hrs. Methanol was removed under vacuum. The residue was purified by column chromatography to get the title compound.

Provenance & Evidence