Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | [5-(Trifluoromethyl)pyridin-3-yl]boronic acid | HCID 45158900 | — |
| Reactant | (2,6-Dichloro-pyrimidin-4-yl)-(2,4-difluoro-benzyl)-amine | HCID 89350889 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | HCID 89350931 | HCID 89350931 | — |
Reaction Steps
A mixture of (2,6-Dichloro-pyrimidin-4-yl)-(2,4-difluoro-benzyl)-amine (1 g, 0.0034 mol) and 5-trifluoromethylpyridine-3-boronic acid (0.726 g, 0.0038 mol) were taken in dioxane:water (20:5) ml and to this CsF (2.1 g, 0.0138 mol) was added and degassed. Then bis-triphenylphosphine-palladium(II) chloride (0.24 g, 0.00034 mol) was added and degassed. The mixture was stirred at 60° C. for 12 hrs. The reaction was cooled to room temperature diluted with water (50 ml) and ethyl acetate (100 ml). After standard work-up, the residue was purified by column chromatography to get compound as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09199962B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-5f6a859c98cb4b198eebfdd35b5928bc |
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| Source note | uspto-grants-2015_12 |
|---|
