Trimethylsilyl iodide → HCID 178523840, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-4-[(6-methoxypyridin-3-yl)methyl]quinoline-2-carboxamide (0.15 g, 0.38 mmol) in CH2Cl2 was added trimethylsilyl iodide (0.15 mL, 1.1 mmol). The reaction mixture was heated to 50° C. for 16 h and cooled to room temperature and concentrated. The resultant residue was subjected to silica gel chromatography eluting with 0-15% methanol in methylene chloride to afford 4-[(6-hydroxypyridin-3-yl)methyl]-N-[(3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl]quinoline-2-carboxamide (L1) that gave a mass ion (ES+) of 380.4 for M+H+.

Provenance & Evidence