Trifluoroacetic acid → HCID 118307490, compound

Participants

Reaction Steps

To a solution of compound 10 (0.7 g, 2.11 mmol) in a mixture of CH2Cl2 (15 mL) and THF (5 mL) at 0° C. was added TFA (5 mL) and the mixture was stirred at room temperature for 6 h. The solvent was evaporated under vacuum to afford 0.66 g (96%) of compound 6 as a dark brown gum. 1H NMR (500 MHz, DMSO-d6) δ=3.17 (m, 4H, 2CH2), 3.40 (m, 4H, 2CH2), 4.28 (s, 2H, CH2), 6.70 (m, 2H, aromatic-H), 6.73 (m, 1H, aromatic-H), 8.81 (br. s, 1H, NH), 8.86 (br. s, 1H, NH). 13C NMR (125.7 MHz, DMSO-d6) δ=46.11 (CH2), 46.70 (CH2), 48.68 (CH2), 112.21 (aromatic-C), 112.27 (aromatic-C), 117.31 (aromatic-C), 130.28 (aromatic-C), 134.99 (aromatic-C), 143.38 (aromatic-C), 154.82 (C═O). Calculated (%) for C14H16F3N4O2 (329.12); C, 51.06; H, 4.90; N, 17.01. found (%); C, 51.01; H, 4.95; N, 16.95.

Provenance & Evidence