p-Toluenesulfonic acid monohydrate → 577778-88-2

Participants

Reaction Steps

p-Toluenesulfonic acid monohydrate (6.62 g) was added to a water-2-butanol (10:1) mixture (55 mL). Subsequently, 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile (7.85 g) was added thereto at 80° C., and the resultant mixture was stirred at 80° C. for 1 hour. The reaction mixture was cooled to room temperature, and the precipitated crystals were recovered through filtration. The crystals were washed with a water-2-butanol (10:1) mixture (40 mL) and dried at 80° C. for 10 hours under reduced pressure, to thereby yield 12.6 g of 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile p-toluenesulfonate.

Provenance & Evidence