反应详情

To a solution of 1-(3-bromo-2,6-difluorophenyl)ethanol (3.91 g) in acetonitrile (50 ml) was added manganese dioxide (2.87 g) at room temperature, and the mixture was heated under reflux for 20 hr. The reaction mixture was cooled, the insoluble material was filtered off, and the obtained filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (3.48 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 20 hr
3. temperatureThe reaction mixture was cooled
4. filtrationthe insoluble material was filtered off
5. concentrationthe obtained filtrate was concentrated under reduced pressure
6. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)