Thionyl Chloride → 2-(Chloromethyl)-5-(trifluoromethyl)thiophene

Participants

Reaction Steps

Thionyl chloride (4.89 g) was added to [5-(trifluoromethyl)thiophen-2-yl]methanol (500 mg) at room temperature, and the mixture was stirred for 3 hr. The reaction mixture was concentrated, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (289 mg).

Provenance & Evidence